Friday, September 19, 2014

SEPTEMBER Is SICKLE CELL DISEASE AWARENESS MONTH!!!


GOOD FRIDAY to ALL of My CRAZY COOL GROOVY Family, friends, Frats, Fans, Followers, Frienemies, and FANTABULICIOSTIACL Funky Fresh Fly Folk of ALL Colors, Shapes, Sizes, Flavors, Persuasions, and Denominations!!!

In 1975, the SICKLE CELL DISEASE ASSOCIATION Of AMERICA (SCDAA) designatd the month of September as SICKLE CELL DISEASE AWARENESS MONTH.

What is SICKLE CELL DISEASE???

SICKLE CELL DISEASE (SCD) or SICKLE CELL ANEMIA (SCA)  is a hereditary blood disorder, characterized by an abnormality in the oxygen-carrying haemoglobin molecule in red blood cells that leads to a propensity for the cells to assume an abnormal, rigid, sickle-like shape under certain circumstances. Sickle-cell disease is associated with a number of acute and chronic health problems, such as severe infections and attacks of severe pain ("sickle-cell crisis"), and an increased risk of death. Sickle-cell disease occurs when a person inherits two abnormal copies of the haemoglobin gene, one from each parent. Several subtypes exist, depending on the exact mutation in each haemoglobin gene.

A person with a single abnormal copy does not experience symptoms and is said to have SICKLE CELL TRAIT (SCT).

The complications of sickle-cell disease can be prevented to a large extent with vaccination, preventative antibiotics, blood transfusion, and the drug hydroxyurea/hydroxycarbamide. A small proportion requires a transplant of bone marrow cells.

Who is most at risk for SCD/SCA???

According to the NATIONAL HEART, LUNG And BLOOD INSTITUTE (NHLBI), it is most common in people whose families come from AFRICA, the CARIBBEAN, CENTRAL and SOUTH AMERICA, INDIA, SOUTH ASIA, and the MEDITERRANEAN.

In the United States, it's estimated that sickle cell anemia affects 70,000–100,000 people, mainly BLACK PEOPLE.

The disease occurs in about 1 out of every 500 BLACK BABIES.

Sickle cell anemia also affects Hispanic Americans. The disease occurs in more than 1 out of every 36,000 Hispanic American births.

More than 2 million Americans have sickle cell trait. The condition occurs in about 1 in 12 BLACK PEOPLE.

What are some COMPLICATIONS of SICKLE CELL DISEASE???

Some of the potential complications of SICKLE CELL DISEASE can include the following:

  • Increased risk of severe bacterial infections due to loss of functioning spleen tissue (and comparable to the risk of infections after having the spleen removed surgically). These infections are typically caused by encapsulated organisms such as Streptococcus pneumoniae and Haemophilus influenzae
  • Stroke, which can result from a progressive narrowing of blood vessels, preventing oxygen from reaching the brain. Cerebral infarction occurs in children and cerebral haemorrhage in adults.
  • Silent stroke is a stroke that causes no immediate symptoms but is associated with damage to the brain. Silent stroke is probably five times as common as symptomatic stroke. 
  • Osteomyelitis (bacterial bone infection); the most common cause of osteomyelitis in sickle-cell disease is Salmonella (especially the non-typical serotypes Salmonella typhimurium, Salmonella enteritidis, Salmonella choleraesuis and Salmonella paratyphi B), followed by Staphylococcus aureus and Gram-negative enteric bacilli perhaps because intravascular sickling of the bowel leads to patchy ischaemic infarction.
  • Opioid tolerance, which can occur as a normal, physiologic response to the therapeutic use of opiates. Addiction to opiates occurs no more commonly among individuals with sickle-cell disease than among other individuals treated with opiates for other reasons.
  • Acute papillary necrosis in the kidneys.
  • Leg ulcers.
  • In eyes, background retinopathy, proliferative retinopathy, vitreous haemorrhages and retinal detachments, resulting in blindness. Regular annual eye checks are recommended.
  • During pregnancy, intrauterine growth retardation, spontaneous abortion, and pre-eclampsia.
  • Chronic pain: Even in the absence of acute vaso-occlusive pain, many patients have chronic pain that is not reported.
  • Pulmonary hypertension (increased pressure on the pulmonary artery), leading to strain on the right ventricle and a risk of heart failure; typical symptoms are shortness of breath, decreased exercise tolerance and episodes of syncope.
  • Chronic renal failure due to sickle-cell nephropathy—manifests itself with hypertension (high blood pressure), proteinuria (protein loss in the urine), haematuria (loss of red blood cells in urine) and worsened anaemia. If it progresses to end-stage renal failure, it carries a poor prognosis.

  • Are there support groups for persons/families dealing with SCD/SCA???

    YES, there are many organizations that offer support and resources for individuals and/or their families.

    They include the aforementioned SCDAA, as well as CHILDREN'S SICKLE CELL FOUNDATION (CSCF)AMERICAN SICKLE CELL ANEMIA FOUNDATION (ASCAF), and the SICKLE CELL FOUNDATION SUPPORT GROUP (SCFSG).

    HAPPY LET'S #BreakTheSickleCycle to #ChompOutSickleCell for SICKLE CELL DISEASE AWARENESS MONTH FRIDAY!!!

    PEACE, LOVE, And BLESSINGS;

    -CCG






     

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